The New Focus Issue of the PMI Journal, The Microenvironment in Human Disease, sheds light on the intricate roles microenvironments play in health and disease. Edited by Peter Østrup Jensen (Copenhagen University Hospital) and Mads Lichtenberg (University of Copenhagen), this issue showcases groundbreaking contributions in pathology, microbiology, and immunology.

As noted by the editors:
“The microenvironment may include the cells, molecules, and structures that surround and support other cells or structures. In human disease, the microenvironment is increasingly being appreciated to provide valuable information with clinical impact.”

Highlights Include:

This issue brings together innovative research on diverse topics, including:
– Cancer Microenvironments: Cancer cells may stimulate aerobic glycolysis through metabolic reprogramming of cancer-associated fibroblasts, enabling elevated energy production.
– Infectious Diseases: The distribution of bacterial physiology may in part explain the successful outcome of antibiotic treatment.
– Chronic Wounds: Chronic wounds harbour both biofilm-growing and planktonic bacteria, posing challenges to novel diagnostic tools being developed targeting only biofilm-growing bacteria.

Diversity and Complexity

This issue underscores the diversity and complexity of microenvironments, providing clinically relevant insights and innovative research approaches.

Explore the full issue here: https://onlinelibrary.wiley.com/toc/16000463/current